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Overview
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Sectors Research & Development
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Company Description
DHEA
DHEA
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Research
Ongoing studies investigate DHEA’s role in aging, hormone regulation, and its potential therapeutic applications. Researchers examine its effects on muscle mass, bone density, and cognitive function.
Education
DHEA is a naturally occurring hormone precursor synthesized by the adrenal glands. It converts into sex hormones like estrogen and testosterone, influencing metabolism and immune response.
Research
Emerging clinical trials assess DHEA’s efficacy in treating conditions such as osteoporosis and depression. Long-term safety studies evaluate risks of supplementation at various doses.
Education
Supplements are marketed for anti-aging and vitality but require medical guidance. Dosage recommendations vary by age, health status, and underlying conditions.
Appointments at Mayo Clinic

Patients seeking personalized DHEA consultations can schedule endocrinology evaluations to assess risks and benefits based on individual hormone levels and health history.
DHEA
Natural production declines with age, prompting interest in supplementation. However, evidence for its anti-aging claims remains inconclusive.
DHEA
Supplements are available over-the-counter but may interact with medications affecting hormone levels or blood sugar regulation.
Overview
DHEA is the most abundant endogenous steroid in humans. Its conversion to sex hormones makes it a focus for studies on aging and hormonal imbalances.
What the research says
Meta-analyses suggest modest benefits in bone density improvement but lack consensus on cardiovascular or cognitive outcomes. Risks of hormone-related side effects persist.
Our take
DHEA supplementation should be approached cautiously, guided by clinical evaluation due to variable responses and potential long-term risks.
Avoid
Pregnant individuals, those with hormone-sensitive cancers (e.g., breast cancer), or liver/kidney issues are advised against DHEA use without medical supervision.
Safety and side effects
Common adverse reactions include acne, hair growth changes, and menstrual irregularities. Rare cases report increased prostate-specific antigen (PSA) levels.
Interactions
DHEA may interfere with diabetes medications, blood thinners, or hormone therapies. Concurrent use of statins requires close monitoring.
From Mayo Clinic to your inbox
Stay informed about DHEA updates through Mayo’s newsletters focused on endocrine health and recent clinical findings.
Mayo Clinic Press
Explore publications detailing DHEA research collaborations and standardized protocols for safe supplementation practices.
About Mayo Clinic
Mayo Clinic contributes to rigorous DHEA trials, emphasizing evidence-based guidelines for patient care and public health advisories.
Medical Professionals
Access DHEA prescribing resources and clinical pathways through Mayo’s professional education portal, including updates on drug interactions.
Businesses
Industry partnerships with Mayo support standardized manufacturing of DHEA supplements aligned with research-driven quality standards.
Students
Medical students can enroll in courses dissecting DHEA’s mechanisms and controversies through Mayo’s educational platform.
Researchers
Mayo facilitates collaborative studies on DHEA’s epigenetic effects and its role in mitigating age-related diseases. Grant opportunities are available for innovative projects.
International Patients
Patients globally consult Mayo experts on cross-border DHEA regulations, efficacy comparisons, and personalized treatment plans.
Follow Mayo Clinic
Engage with Mayo’s social channels sharing expert insights into DHEA research breakthroughs and patient testimonials under medical guidance.